8/9/2023 0 Comments Zoloft insomnia benadrylWe found that this level of use was associated with a 10-percentage-point increase in the probability that an exposed person will experience dementia onset before an unexposed person. For instance, we estimated that on average, people taking at least 10 mg/day of doxepin, 50 mg/day of diphenhydramine, 4 mg/day of chlorpheniramine, or 5 mg/day of oxybutynin every day for more than three years would be at greater risk for developing dementia. The risks that we found are at the population level. Many people who take these medications will never develop dementia or pneumonia. Q: Will I get dementia, or pneumonia, because I’ve taken an anticholinergic medication?Ī: Not necessarily. Diphenhydramine (Benadryl in the United States) is often found in common sleep aids as well. Q: Which medications have strong anticholinergic effects?Ī: In our research, the most commonly used strong anticholinergic medications were older antidepressants like doxepin (Sinequan), first-generation antihistamines like diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton), and antimuscarinics for bladder control like oxybutynin (Ditropan). Medications that block acetylcholine’s action can cause side effects including drowsiness, constipation, difficulty urinating, and dry mouth and eyes. Acetylcholine is a neurotransmitter that sends signals in the nervous system. We hope these questions and answers will be helpful: Q: What are anticholinergic drugs?Ī: These medications block the action of acetylcholine in the brain and body. Many patients and doctors have shared their concerns about our recent research linking use of larger amounts of common medications that have strong anticholinergic side effects to higher risks for developing pneumonia and dementia, including Alzheimer’s disease. Larson explore how to balance the risks and benefits of these common medications.
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